What Is Regenerative Medicine?
- Uses stem cells and growth factors
- Repair or replace damaged and defective tissues and organs
- Create living and functional tissues (not scar)
What Is a Stem Cell?
- These are repair cells that are “looking for a job”
- Stem cells can proliferate (replicate into more stem cells)
- Stem cells can differentiate (turn into other specific cells or tissues)
- These actions are based on signals (Growth Factors) from damaged tissues
- How do stem cells heal?
How Do Stem Cells Heal?
- Homing Property – Cells respond to appropriate cytokine signals released from tissue injury, inflammation, degeneration, disease, or cell death.
- Activation Property – Cells promote cytokine mediated paracrine and autocrine effects to repair damaged target tissue. Cells may engraft and trans-differentiate into needed tissue in some cases.
Bone Marrow vs. Fat Derived Cells
- Bone marrow is deficient and suppressed in chronic illness. Fat is not.
- Bone marrow has less cell numbers associated with aging. Fat derived cells change less with age.
- Fat derived cells are essentially equally effective in forming new tissue and may even be superior for some conditions (myocardial regeneration or chondrogenesis).
- Bone marrow hurts
- SVF can be used IV
Why Inject Additional Stem Cells?
- Stem call BIOAVAILABILITY – dormant calls made available to damaged tissue
- When additional stem cell are added to injured areas in large numbers they can effect therapeutic changes
- Can exert local and systemic changes
IRB Approved Protocols