Repair or replace damaged and defective tissues and organs
Create living and functional tissues (not scar)
What Is a Stem Cell?
These are repair cells that are “looking for a job”
Stem cells can proliferate (replicate into more stem cells)
Stem cells can differentiate (turn into other specific cells or tissues)
These actions are based on signals (Growth Factors) from damaged tissues
How do stem cells heal?
How Do Stem Cells Heal?
Homing Property – Cells respond to appropriate cytokine signals released from tissue injury, inflammation, degeneration, disease, or cell death.
Activation Property – Cells promote cytokine mediated paracrine and autocrine effects to repair damaged target tissue. Cells may engraft and trans-differentiate into needed tissue in some cases.
Bone Marrow vs. Fat Derived Cells
Bone marrow is deficient and suppressed in chronic illness. Fat is not.
Bone marrow has less cell numbers associated with aging. Fat derived cells change less with age.
Fat derived cells are essentially equally effective in forming new tissue and may even be superior for some conditions (myocardial regeneration or chondrogenesis).
Bone marrow hurts
SVF can be used IV
Why Inject Additional Stem Cells?
Stem call BIOAVAILABILITY – dormant calls made available to damaged tissue
When additional stem cell are added to injured areas in large numbers they can effect therapeutic changes
